In Path of Exile (PoE) and Path of Exile 2 (PoE 2), farming Orbs of Alchemy is a key activity for players who want to improve their gear and crafting capabilities. Orbs of Alchemy are a useful currency item that upgrades normal items into rare ones, so knowing the best spots to farm these orbs can significantly boost gameplay efficiency. Much like managing cheap poe 2 currency, farming methods require both strategy and consistency to maximize rewards.

One of the best farming spots, especially in PoE 2, is Act 2's Lost City. This area is known for its treasure chests and mini-bosses, whose defeat can yield various crafting materials including Orbs of Alchemy. The Lost City provides a good balance of enemy density and valuable loot, making it suitable for farming orbs regularly. Running this zone repeatedly, especially in higher difficulty levels like Cruel, increases the chances of orb drops due to the enhanced loot tables.

Another highly recommended location is the Molten Vault found in Act 3. This zone is rich with elite enemies and numerous chests, providing ample opportunities to pick up rare items and currency drops including Orbs of Alchemy. The Molten Vault's layout allows for efficient clear times and quick resets, which makes it ideal for farming. Clearing this area consistently yields not just Orbs of Alchemy but also other valuable orbs like Regal and Chaos Orbs, which can help build wealth and crafting resources.

In addition to these zone-specific spots, farming endgame maps and zones with high monster density also tends to be rewarding. Higher-level and higher-difficulty maps naturally drop more valuable currency, including Orbs of Alchemy, particularly when running quantity and rarity-boosting mods. Some players focus on boss farming techniques, where they repeatedly kill bosses that have higher chances to drop Orbs of Alchemy alongside other valuable items.

Efficient farming also includes vendor recipes and league mechanics as indirect methods to acquire Orbs of Alchemy. Selling unidentified rare gear sets to vendors can occasionally reward Orbs of Alchemy, adding a passive way of collecting these orbs while clearing zones. Moreover, certain divination cards and league-specific content or mechanics sometimes offer Orbs of Alchemy as rewards, providing additional farming pathways outside of enemy drops.

A notable advanced farming method in PoE 2 involves farming a specific boss in Helani Gates, Act 2 Cruel difficulty area, on repeat. Players employ a strategy where they consume the boss's body or use particular items to reset the boss fight quickly after each kill, farming consistent rare drops including Orbs of Alchemy. This method is highly efficient for players looking to stockpile orbs in a short amount of time.

To maximize orb farming efficiency, players should focus on areas with dense enemy populations, plentiful loot chests, and bosses that drop rare items regularly. Resetting instances via waypoints to farm the same areas repeatedly is a common technique. Balancing speed with loot yield is key, so finding routes that allow quick clear times with high drop potential is the best approach.

The best farming spots for Orbs of Alchemy include the Lost City in Act 2, the Molten Vault in Act 3, and specific endgame boss farming locations like Helani Gates. Combining regular zone clears with vendor recipes and league mechanic rewards can enhance orb acquisition rates. Much like learning when to buy poe 2 currency, developing smart farming routines and understanding the game’s loot dynamics are essential to efficiently gather Orbs of Alchemy for crafting and upgrading gear.