1. Upgrade the Right Base Items
   Focus on using Orbs of Transmutation on normal (white) items that have good base stats, sockets, or item levels. For example, weapons with solid base damage or boots with potential movement speed are excellent candidates. Avoid wasting orbs on low-quality items you will soon replace, especially if you're looking to buy poe 2 currency for sale to complement your crafting strategy.

2. Enhance Utility Flasks Early
   Turn basic flasks into magic flasks with helpful affixes like freeze immunity, curse immunity, or increased movement speed. This early utility greatly improves survivability, especially in challenging content. Keep your life and mana flasks upgraded as well. Upgrading these essential items early on is a smart move in your journey.

3. Combine with Other Currency for Better Crafting
   After creating a magic item with one affix using a Transmutation Orb, you can add a second affix with an Orb of Augmentation or upgrade it to a rare using a Regal Orb. This step-by-step crafting sequence allows you to manage your resources and improve gear gradually, while ensuring that you don’t overspend on resources like poe 2 currency.

4. Farm and Maintain a Steady Supply
   Collect Orbs of Transmutation both from monster drops in high-density areas and by disenchanting unused magic items at vendors to get Transmutation Shards. Ten shards combine into one orb, ensuring you have a healthy stock of currency for ongoing upgrades. Be sure to target areas that maximize orb drops to ensure you’re constantly stocked.

5. Use Selectively, Don’t Hoard or Waste
   Avoid hoarding too many orbs without using them, but also don’t waste them on bad bases or items you quickly outgrow. Experiment with different base items to find which affixes best suit your build. Use orbs regularly to keep your equipment competitive through each act, ensuring a steady progression in your gameplay.

Following these tips will help you make the most out of Orbs of Transmutation, enabling steady gear improvements and smoother progression from early acts to endgame crafting, whether you're working with or without additional poe 2 currency at your disposal.