In Path of Exile 2 Trade, players encounter a wide array of quests that bring both narrative depth and exciting challenges. One such quest, Tribal Medicine, delves into the ancient traditions of the indigenous cultures within the game's world. This quest not only introduces players to the spiritual and medicinal practices of these tribes but also challenges them with unique tasks involving alchemy, herbalism, and mystical rituals.

In this guide, we’ll walk you through the Tribal Medicine Quest, offering an in-depth look at the objectives, steps, and tips on how to complete it efficiently. Whether you’re a newcomer to Path of Exile 2 or an experienced player, this quest will test your strategic thinking, exploration, and combat skills.

Quest Overview

The Tribal Medicine quest is primarily concerned with helping a native tribal healer, known as the Shaman, who is struggling to heal the sick and wounded members of their tribe. The local environment is plagued with dangerous fauna, poisonous plants, and spiritual curses, which makes the task even more complex. Throughout the quest, you will be tasked with gathering medicinal plants, facing spirit guardians, and uncovering ancient tribal secrets that will help you craft a powerful remedy capable of saving the tribe.

The quest involves multiple stages, each requiring you to venture into dangerous areas, defeat various enemies, and solve puzzles. You’ll also need to interact with local tribal NPCs, learning about their culture, practices, and the challenges they face. As you progress, you will unlock new abilities and gain valuable rewards, including rare herbs and potent crafting materials.

Starting the Tribal Medicine Quest

To begin the Tribal Medicine quest, you must first reach Act 3 in Path of Exile 2. The quest is unlocked after you have completed certain story objectives and have established a connection with the indigenous tribes in the game world. You will be introduced to the quest by the Tribal Shaman in a small village located deep within the forest or jungle region.

Step 1: Speak to the Shaman

The quest begins when you speak with the Shaman, a wise tribal healer who is struggling with an outbreak of a deadly disease among their people. The Shaman believes that the disease is connected to the land itself, possibly caused by a disruption of the natural balance. To save the tribe, the Shaman requests your help in gathering rare medicinal herbs and performing an ancient healing ritual.

You will be provided with a list of objectives, including specific plants and ingredients to find. These items are scattered across different regions, and their locations are often hidden or protected by dangerous creatures.

Step 2: Gather Medicinal Plants

The first part of the quest involves gathering rare herbs and medicinal plants that are scattered around the environment. You’ll need to explore the dense jungle or forest areas, which are filled with hostile wildlife, traps, and other dangers. Some plants will be guarded by aggressive creatures, while others might be hidden in hard-to-reach areas, requiring you to use your climbing or traversal abilities.

The medicinal plants you need to collect will be marked on your map, but they are often located in locations that require careful exploration. As you gather these herbs, you will also encounter spirit guardians — powerful, ethereal creatures tied to the natural world. These spirits will challenge you with combat encounters, requiring you to defeat them to proceed.

Here’s a list of some key herbs you will likely need:

Virok Root: A common medicinal root used in anti-poison treatments.

Sacred Blossom: A rare flower that grows only near sacred shrines in the jungle.

Vial of Soul Resin: A potent alchemical ingredient that can heal spiritual wounds.

Moonvine: A glowing vine used in calming rituals for agitated spirits.

These plants are not just useful for healing but also play a role in crafting potions and elixirs that may aid you during difficult encounters.

Step 3: Spirit Trials and Rituals

Once you’ve collected the necessary plants, the next part of the quest involves facing the Spirit Trials, a series of mystical challenges set by the tribal shamans. These trials test your ability to connect with the spirits of the land and prove your worthiness to perform the sacred healing ritual.

The Spirit Trials consist of multiple phases:

Combat Trials: You’ll face off against spirit-infused enemies that are imbued with elemental powers. These enemies will vary in strength and abilities, so you’ll need to adapt your strategies to defeat them.

Puzzle Trials: Some trials require you to solve complex environmental puzzles. These puzzles are designed to challenge your observation and logic, often requiring you to use the plants and ingredients you’ve gathered.

Sacred Rituals: In this phase, you must perform a series of rituals at specific locations in the jungle or forest. These rituals involve arranging the plants you’ve collected in specific patterns, chanting sacred words, and using your alchemical knowledge to combine the ingredients into powerful healing elixirs.

During this stage, you may also encounter ancient Totem Guardians, powerful creatures that protect sacred sites. Defeating these guardians will allow you to access hidden locations where the rituals must be performed.

Step 4: Confront the Cursed Beast

After completing the Spirit Trials, you will discover that the disease afflicting the tribe is actually the result of a Cursed Beast — a powerful spirit that was once bound to protect the land but has become corrupted by a dark force. The beast is now causing the outbreak by spreading spiritual decay across the tribe’s territory.

The Cursed Beast is not just a simple boss fight — it is a multi-phase encounter that requires you to weaken it using the medicinal herbs you have crafted during the quest. You must first locate the beast, which will be hidden deep within the jungle or forest, often in areas that are hard to access without the help of tribal guides or magic.

Cursed Beast Encounter:

First Phase: The Cursed Beast is surrounded by spiritual minions that it commands. These minions are fast, numerous, and can cause chaos in battle. During this phase, focus on clearing the minions and dealing damage to the beast.

Second Phase: Once the minions are defeated, the Cursed Beast will enter a frenzied state, unleashing powerful attacks that can devastate your character. You will need to use healing potions, buffs, and defensive abilities to stay alive during this phase.

Final Phase: The beast will unleash its full spiritual power, causing environmental hazards like poisonous gas clouds, fire eruptions, and ethereal shockwaves. At this point, use the medicinal elixirs you’ve crafted to weaken the beast and purify it with the power of the sacred plants.

Defeating the Cursed Beast will cleanse the land of its corruption, saving the tribe from further harm and restoring balance to the spiritual forces in the region.

Step 5: Completing the Ritual and Saving the Tribe

After defeating the Cursed Beast, you’ll return to the Shaman with the news of your success. However, the Shaman will still require your help to complete the healing ritual and ensure the tribe’s safety. You will perform the final rituals using the herbs you’ve gathered and purified in the spirit trials. This is a significant moment in the quest, as you will witness the culmination of the Shaman’s teachings and the importance of the natural balance in the world.

Once the ritual is complete, the tribe’s people will be healed, and the area will be restored to its former glory. The Shaman will reward you with rare crafting materials, tribal artifacts, and a unique charm that enhances your connection to the spiritual forces in the game.

Rewards for Completing the Tribal Medicine Quest

Completing the Tribal Medicine quest rewards players with the following:

Experience Points: Significant experience for advancing your character and unlocking new abilities.

Healing Elixirs: Unique potions that increase your health regeneration and reduce status ailments.

Tribal Relics: Special crafting materials that can be used to enhance your gear, creating powerful items imbued with nature’s essence.

Tribal Reputation: An increase in your standing with the tribal faction, unlocking new quests, abilities, and items from the Shaman and other tribes.

Tips for Completing the Tribal Medicine Quest

Explore Thoroughly: The herbs and ingredients required for the quest can be well-hidden, so make sure to explore every corner of the jungle or forest.

Prepare for Spirit Trials: Equip gear that enhances your resistance to elemental damage, as the Spirit Trials and Cursed Beast encounter often feature elemental hazards.

Craft and Use Elixirs: Always have your crafted elixirs on hand during the Spirit Trials and boss fights. These potions can save you in tight situations.

Use the Environment: The environment can help you during boss fights — utilize terrain features like high ground, traps, and obstacles to gain an advantage over your enemies.

Conclusion

The Tribal Medicine quest in Path of Exile 2 is a rich and immersive journey that intertwines spiritual traditions, herbalism, and combat. It challenges players to not only fight enemies but also understand and engage with the world’s deep cultural and mystical aspects. By following this guide and preparing carefully, you will be able to complete the quest, helping the tribe heal and unlocking valuable rewards in the process. Whether you’re seeking a greater connection to the game’s lore or looking for powerful items to buy POE 2 Orbs in your adventure, this quest offers an experience that enriches the Path of Exile 2 world.